In Baldur's Gate 3, before a player reaches the final "endings" of the game, it is sometimes possible for players to encounter a "Game Over" screen as the result of a conversation option or fail condition during a combat encounter. Reaching a Game Over will not offer scenes or conversations that conclude the overall story of the campaign, but will cause a screen to appear that prompts the player to reload from a prior save.

This wiki wants to treat an "Ending" as being a different concept from a "Game Over", and will organize endings on a separate page.
Main Article: Endings

Known Cases of Game Over Screens

Grouped by the "Earliest Opportunity" that the screen can trigger.

General

General phenomenon that result in a Game Over, regardless of act or method to arrive at the screen

Fail to prevent your own Ceremorphosis, or do something that causes you to lose what protection you did have against it.
With Gale recruited or as the selected Origin, fail to prevent the Orb from exploding after you become aware of its existence.

Note: Some game-over triggers may not fire during co-op gameplay. Keep in mind that this information is not always accessible for a single contributor to confirm.

Prologue

Act One

In Case of Death... - Triggered by failing to complete this quest within three long rests of when it is started.
Crèche Y'llek (multiple intersecting quests) - Triggered during conversation with Vlaakith, by selecting conversation options that convince her to "prove her godhood" to the party.
Find the Blood of Lathander - Triggered by attempting to take 'the blood' by "using force" and failing to escape or stop the big trap from firing before the turn counter runs out.

Act Two

Use a certain ability that becomes available to Gale as early as the start of Act Two.

Act Three

Help Your Protector - Triggered in combat, if your 'protector' ends up hitting zero hit points.
House of Hope - Triggered during conversation with Haarlep, by selecting conversation options that result in you "giving up" both your mind and your body.
Iron Throne - Triggered if the player fails to escape the area before the turn counter expires.
Confront the Elder Brain (multiple):
- Triggered if the player fails to finish casting a specific spell before the turn counter expires.

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