Game Over screens

In Baldur's Gate 3, before a player reaches the final "endings" of the game, it is sometimes possible for players to encounter a "Game Over" screen as the result of a conversation option or fail condition during a combat encounter. Reaching a Game Over will not offer scenes or conversations that conclude the overall story of the campaign, but will cause a screen to appear that prompts the player to reload from a prior save.

This wiki wants to treat an "Ending" as being a different concept from a "Game Over", and will organize endings on a separate page.
Main Article: Endings

Known Cases of Game Over Screens

Grouped by the "Earliest Opportunity" that the screen can trigger.

General

General phenomenon that result in a Game Over, regardless of act or method to arrive at the screen

• Fail to prevent your own Ceremorphosis, or do something that causes you to lose what protection you did have against it.
• With Gale recruited or as the selected Origin, fail to prevent the Orb from exploding after you become aware of its existence.

Note: Some game-over triggers may not fire during co-op gameplay. Keep in mind that this information is not always accessible for a single contributor to confirm.

Act One

• In Case of Death... - Triggered by failing to complete this quest within three long rests of when it is started.
• Crèche Y'llek (multiple intersecting quests) - Triggered during conversation with Vlaakith, by selecting conversation options that convince her to "prove her godhood" to the party.

Act Two

• Use a certain ability that becomes available to Gale as early as the start of Act Two.

Act Three

• Help Your Protector - Triggered in combat, if your 'protector' ends up hitting zero hit points.
• House of Hope - Triggered during conversation with Haarlep, by selecting conversation options that result in you "giving up" both your mind and your body.
• Iron Throne - Triggered if the player fails to escape the area before the turn counter expires.
• Confront the Elder Brain (multiple):
  • Triggered if the player fails to finish casting a specific spell before the turn counter expires.