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The Prologue of Baldur's Gate 3 takes place immediately after the opening cinematic, in which the main character is infected with a Mind Flayer larva. The Nautiloid in which this takes place is attacked by Githyanki warriors, allowing the main character to break free. The objective of the Prologue is to find a way out of the Nautiloid.
Quests
Find a way off the Nautiloid.
We've been abducted by mind flayers and infected with some kind of parasite. We need to find a way off this ship.
Areas
Nursery room
This is the room in which the game begins; the main character has broken free out of a Mind Flayer Pod and is standing alone in the room. Around the room there are various empty mind flayer pods indicating that there might be other survivors.
In the middle of the room there is a mind flayer "nursery" i.e. a pool filled with larvae. Upon interacting with it, you can Investigate it to determine that it's about to break apart, or try to touch it in which case it explodes and causes a small amount of damage to your character.
To the south of the nursery you can find a dead mind flayer. Looting him yields a Spiked Bulb.
Further south you can climb up to a small elevation in the room, where a dead mind flayer Thrall can be looted for a Scroll of Mage Armour and 3gp. Lying aside him is a Slave Mind --a human brain preserved in a jar-- that can be picked up.
To the east of the room, slightly southward, you can go up to a larger elevated area of the room, circling around it all the way to the northwest. Along this elevated area you can find: 1. a Cartilaginous Chest containing a Potion of Healing and a Potion of Fire Resistance, 2. a Caustic Bulb lying on a table, and 3. a second Cartilaginous Chest containing a bottle of Alchemist's Fire and a Grease Bottle.
On the west side of the room you will find an illithid restoration device and a door to the next room.
Brain room
The dead bodies of three Lesser Imps will greet you in this room. Loot them for a Potion of Healing and a Scroll of Fire Bolt. Directly to your side there is a table with an Illithid Record and a Hollow Shell.
A table to the north has a Caustic Bulb, three Mucoid Shells, a Sodalite Shell, and a Barbed Device. Westwards and further north from it is a table on which you can find an Eldritch Tablet, an Illithid Manuscript, and a Dark Mind.
In the middle of the room, a small elevator can get you to an elevated section of the room. Here you will find a dying person sitting on a chair with their scalp removed, their exposed brain telepathically asking you for help. Otherwise, the elevated part of the room contains a pair of cartilaginous chests containing random loot.
TODO: interactions with brain
To the west of the room there's an opening in the Nautiloid's shell. An outer path leads to the north, where you have to jump over a gap and will have your first encounter with the Githyanki soldier Lae'zel, who was previously seen in the opening cinematic also being infected with a larva.
Imp battle room
TODO: continue this...